Effect of cordycepin on the expression of the inflammatory cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 mice.
نویسندگان
چکیده
Culture supernatants of splenocytes from C57BL/6 mice were exposed to 0.3, 1.0, and 3.0 microg/ml cordycepin plus 3.0 microg/ml lipopolysaccharide (LPS) to investigate the effects of cordycepin (3'-deoxyadenosine) on the production of inflammatory cytokines. Co-administration of 3.0 microg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. These findings suggest that cordycepin down-regulates the immediate hypersensitivity reaction stimulated by LPS.
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عنوان ژورنال:
- Journal of microbiology and biotechnology
دوره 23 2 شماره
صفحات -
تاریخ انتشار 2013